Codeine can't do it: Fatal forty DDI: Codeine, fluoxetine, CYP2D6

Katarina Bojanić, Wayne T. Nicholson, Erica D. Wittwer, Toby N. Weingarten, Juraj Sprung

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


This case discusses a pharmacokinetic interaction between the prodrug codeine and fluoxetine. Codeine is converted to its active metabolite morphine by cytochrome P450 2D6. Fluoxetine is a 2D6 inhibitor.

Original languageEnglish (US)
Title of host publicationA Case Approach to Perioperative Drug-Drug Interactions
PublisherSpringer New York
Number of pages5
ISBN (Print)9781461474951, 9781461474944
StatePublished - Sep 15 2015

ASJC Scopus subject areas

  • General Medicine


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