Coccidioidomycosis in patients with hematologic malignancies

Janis E. Blair, Jerry D. Smilack, Sean M. Caples

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


Background: An endemic fungal infection of the desert southwestern United States, coccidioidomycosis is generally a self-limited illness in healthy persons. Immunosuppressed persons who contract coccidioidomycosis, however, are at increased risk for disseminated infection. Methods: We conducted a retrospective review of patients with coccidioidomycosis and hematologic malignancy or bone marrow disease. Results: Fifty-five patients were identified. The most common underlying malignancies were non-Hodgkin lymphoma and chronic lymphocytic leukemia. Extrathoracic (or disseminated) infection was observed in 12 patients (22%). Fifteen patients (27%) died with active coccidioidomycosis. Treatment of the hematologic disease with corticosteroids or antineoplastic chemotherapy increased the risk of death. Conclusion: To date, this is the largest case series of patients with hematologic malignancy and coccidioidomycosis. In persons with hematologic malignancy, coccidioidomycosis can be a severe illness with a high risk for disseminated infection and death.

Original languageEnglish (US)
Pages (from-to)113-117
Number of pages5
JournalArchives of internal medicine
Issue number1
StatePublished - Jan 10 2005

ASJC Scopus subject areas

  • Internal Medicine


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