Co-existent epicardial paraganglioma and anterior mediastinal thymoma

Matthew G. Dudgeon, Sushilkumar K. Sonavane, Ephraim E. Parent, Andras Khoor, Mathew Thomas

Research output: Contribution to journalArticlepeer-review


Thymoma and paraganglioma are known causes of mediastinal masses, the latter being extremely rare. Thymomas arise from remnant thymic tissue in the anterior mediastinum; whereas, thoracic paragangliomas arise from paraaortic or para-vertebral sympathetic chain ganglion (derivatives of embryonic neural crest) in the middle or posterior mediastinum. We report a case of a middle-aged woman with two mediastinal masses, originally believed to be a single tumor or primary malignancy with adjacent metastasis on Computed Tomography (CT) that were further delineated with Magnetic Resonance Imaging (MRI) and [68Ga]-DOTA-(Tyr3)-octreotate (DOTA-TATE) Positron Emission Tomography-Computed Tomography (PET-CT) and surgical pathology as two distinct entities: left epicardial paraganglioma and anterior mediastinal thymoma. A comprehensive discussion of both entities is included.

Original languageEnglish (US)
Pages (from-to)16-30
Number of pages15
JournalJournal of Radiology Case Reports
Issue number10
StatePublished - Oct 2020


  • CT
  • Cardiac
  • Epicardial
  • Gallium-68 DOTA-TATE
  • Hereditary
  • MRI
  • Mediastinal Mass
  • PET-CT
  • Paraganglioma
  • Succinate dehydrogenase (SDH) subunits
  • Thymoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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