Cluster headache

Dw Dodick, Td Rozen, Pj Goadsby, Stephen D. Silberstein

Research output: Contribution to journalReview articlepeer-review

157 Scopus citations


Cluster headache is a stereotypic, primary headache disorder that is marked by repeated short-lasting attacks of severe, unilateral head pain and associated autonomic symptoms. Cluster headache is probably due to an abnormality in the circadian hypothalamic generator with subsequent trigeminovascular activation. We have reviewed the clinical manifestations, pathophysiology, gender differences, and treatment options in cluster headache.

Original languageEnglish (US)
Pages (from-to)787-803
Number of pages17
Issue number9
StatePublished - 2000


  • Antiepileptic agents
  • Circadian cycle
  • Cluster
  • Headache
  • Hypothalamus

ASJC Scopus subject areas

  • Clinical Neurology


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