Clot Pathophysiology: Why Is It Clinically Important?

Patrick A. Brouwer, Waleed Brinjikji, Simon F. De Meyer

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Cerebral ischemic stroke treatment may change significantly now that clots are actually physically removed from the patient using thrombectomy. This allows for an analysis of the content of the clots as well as the correlation of the imaging findings and the clot behavior and morphology. This article illustrates how the interaction of different clots varies in the clinical setting and how analysis of clot composition, as well as the search for new pharmacologic targets, can lead to a better understanding of the pathophysiology and therapy resistance, in turn providing possibilities for a better approach in the treatment.

Original languageEnglish (US)
Pages (from-to)611-623
Number of pages13
JournalNeuroimaging Clinics of North America
Issue number4
StatePublished - Nov 2018


  • Blood clot
  • Cerebral ischemic stroke
  • Etiology
  • Pathophysiology
  • Thrombectomy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology


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