Clonal relationships between malignant lymphomas and histiocytic/dendritic cell tumors

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3 Scopus citations


Tumors of histiocytic or dendritic cell origin appear to occur with increased frequency in patients with lymphoma. Recent molecular data have demonstrated clonal relationships between the lymphoma and the histiocytic/dendritic cell tumor in some of these cases. Clinical, pathologic, and experimental data suggest that this phenomenon probably represents transdifferentiation of the lymphoma clone to a histiocytic/dendritic cell lineage in most cases. Awareness of this entity is necessary to prompt comparative molecular studies in appropriate cases.

Original languageEnglish (US)
Pages (from-to)619-629
Number of pages11
JournalSurgical Pathology Clinics
Issue number4
StatePublished - Dec 2013


  • Clonality
  • Dendritic cell tumor
  • Histiocytic sarcoma
  • Langerhans cell histiocytosis
  • Lineage plasticity
  • Transdifferentiation
  • Transformation

ASJC Scopus subject areas

  • Surgery
  • Pathology and Forensic Medicine


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