Clomiphene citrate for treatment refractory chronic cluster headache

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A treatment refractory chronic cluster headache patient is presented who became cluster-free on clomiphene citrate. The author has previously reported a SUNCT patient responding to clomiphene citrate. Hypothalamic hormonal modulation therapy with clomiphene citrate may become a new preventive choice for trigeminal autonomic cephalalgias. The possible mechanism of action of clomiphene citrate for cluster headache prevention will be discussed.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
Issue number2
StatePublished - Feb 2008


  • Clomiphene citrate
  • Cluster headache
  • Headache
  • Suprachiasmatic nucleus
  • Testosterone
  • Trigeminal autonomic cephalalgias

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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