Clinicopathologic features, diagnosis, and treatment of fibrosarcoma of bone.

Panayiotis J. Papagelopoulos, Evanthia C. Galanis, Pantelis Trantafyllidis, Peter J. Boscainos, Franklin H. Sim, K. Krishnan Unni

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Fibrosarcoma of bone is a relatively rare tumor; it accounts for less than 5% of bone sarcomas. The anatomical sites most commonly involved are the metaphyses of long tubular bones. Local pain, swelling, limitation of motion, and pathologic fracture are the common clinical signs and symptoms. Typical imaging findings include eccentrically located lytic lesions, with a geographic, moth-eaten, or permeative pattern of bone destruction, and extension into adjacent soft tissues. Surgery is the treatment of choice. The type of surgical procedure depends mainly on histologic grade, local conditions, and tumor location. With a high probability of metastases (>70%) after surgical treatment, perioperative adjuvant treatment modalities should be considered for high-grade tumors. The most important prognostic factors affecting survival include tumor grade, patient's age, and tumor location.

Original languageEnglish (US)
Pages (from-to)253-257
Number of pages5
JournalAmerican journal of orthopedics (Belle Mead, N.J.)
Issue number5
StatePublished - May 2002

ASJC Scopus subject areas

  • General Medicine


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