Clinical trials of mitotic kinesin inhibitors

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Abnormal mitotic activity underlies the pathology of a number of human diseases, most notably cancer, and has motivated the search for more specific and less toxic inhibitors of the mitotic process. In this chapter, I review the clinical experience with one group of inhibitors that target mitotic kinesins. I will discuss the results of phase I and II trials with these drugs and place the results of these trials in a context to explain how they can be utilized in future human studies.

Original languageEnglish (US)
Title of host publicationKinesins and Cancer
PublisherSense Publishers
Number of pages14
ISBN (Electronic)9789401797320
ISBN (Print)9789401797313
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)


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