Clinical trials of mitotic kinesin inhibitors

Steven S. Rosenfeld

doi:10.1007/978-94-017-9732-0_4

Clinical trials of mitotic kinesin inhibitors

Steven S. Rosenfeld

Hematology / Oncology / Cancer Center / Breast Clinic

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Abnormal mitotic activity underlies the pathology of a number of human diseases, most notably cancer, and has motivated the search for more specific and less toxic inhibitors of the mitotic process. In this chapter, I review the clinical experience with one group of inhibitors that target mitotic kinesins. I will discuss the results of phase I and II trials with these drugs and place the results of these trials in a context to explain how they can be utilized in future human studies.

Original language	English (US)
Title of host publication	Kinesins and Cancer
Publisher	Sense Publishers
Pages	63-76
Number of pages	14
ISBN (Electronic)	9789401797320
ISBN (Print)	9789401797313
DOIs	https://doi.org/10.1007/978-94-017-9732-0_4
State	Published - Jan 1 2015

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology
General Chemistry

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10.1007/978-94-017-9732-0_4

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Clinical trials of mitotic kinesin inhibitors

Abstract

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