Clinical significance of serum autoantibodies in idiopathic interstitial pneumonia

Bo Hyoung Kang, Jin Kyeong Park, Jae Hyung Roh, Jin Woo Song, Chang Keun Lee, Miyoung Kim, Se Jin Jang, Thomas V. Colby, Dong Soon Kim

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Although autoantibodies are routinely screened in patients with idiopathic interstitial pneumonia, there are no reliable data on their clinical usefulness. The aim of this study was to investigate the prognostic value of autoantibodies for predicting the development of new connective tissue disease in these patients and also mortality. We conducted retrospective analysis of the baseline, and follow-up data for 688 patients with idiopathic interstitial pneumonia (526with idiopathic pulmonary fibrosis, 85 with nonspecific interstitial pneumonia, and 77 with cryptogenic organizing pneumonia) at one single tertiary referral center. The median follow-up period was 33.6 months. Antinuclear antibody was positive in 34.5% of all subjects, rheumatoid factor in 13.2%, and other specific autoantibodies were positive between 0.7%-6.8% of the cases. No significant difference in patient survival was found between the autoantibody-positive and -negative groups. However, the presence of autoantibodies, especially antinuclear antibody with a titer higher than 1:320, was a significant predictor for the future development of new connective tissue diseases (relative risk, 6.4), although the incidence was low (3.8% of all subjects during follow-up). In conclusion, autoantibodies are significant predictors for new connective tissue disease development, although they have no prognostic value.

Original languageEnglish (US)
Pages (from-to)731-737
Number of pages7
JournalJournal of Korean medical science
Issue number5
StatePublished - May 2013


  • Antinuclear antibody
  • Autoantibody
  • Connective tissue disease
  • Cryptogenic organizing pneumonia
  • Idiopathic interstitial pneumonias
  • Idiopathic pulmonary fibrosis
  • Incidence
  • Nonspecific interstitial pneumonia
  • Predictive factor
  • Rheumatoid factor

ASJC Scopus subject areas

  • General Medicine


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