Clinical presentation of autoimmune and viral encephalitides

Divyanshu Dubey, Michel Toledano, Andrew McKeon

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Purpose of review We describe clinical and diagnostic features of various autoimmune and viral encephalitis subtypes. Recent findings Population-based studies have demonstrated both autoimmune and viral causes have similar prevalence and incident rates. Repertoire of autoimmune biomarkers has considerably increased with discovery of many novel neural antibodies including glial fibrillary acidic proteinα-immunoglobulin G. Similarly, with use of next generation sequencing and DNA libraries, many viral causes are being detected which would have been categorized as encephalitis of unknown cause a decade ago. Summary Autoimmune and viral encephalitides can resemble one another and sometimes autoimmune encephalitis may be triggered by viral infections. Early diagnosis and treatment is the key to both causes, which emphasizes the importance of clinical diagnosis before laboratory confirmation.

Original languageEnglish (US)
Pages (from-to)80-90
Number of pages11
JournalCurrent Opinion in Critical Care
Issue number2
StatePublished - Apr 1 2018


  • autoimmune
  • encephalitis
  • limbic encephalitis
  • virus

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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