@article{1a0097a4db154be38d001bd7174f56ce,
title = "Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update",
abstract = "Thiopurine methyltransferase (TPMT) activity exhibits a monogenic codominant inheritance and catabolizes thiopurines. TPMT variant alleles are associated with low enzyme activity and pronounced pharmacologic effects of thiopurines. Loss-of-function alleles in the NUDT15 gene are common in Asians and Hispanics and reduce the degradation of active thiopurine nucleotide metabolites, also predisposing to myelosuppression. We provide recommendations for adjusting starting doses of azathioprine, mercaptopurine, and thioguanine based on TPMT and NUDT15 genotypes (updates on www.cpicpgx.org).",
author = "Relling, {Mary V.} and Matthias Schwab and Michelle Whirl-Carrillo and Guilherme Suarez-Kurtz and Pui, {Ching Hon} and Stein, {Charles M.} and Moyer, {Ann M.} and Evans, {William E.} and Klein, {Teri E.} and Antillon-Klussmann, {Federico Guillermo} and Caudle, {Kelly E.} and Motohiro Kato and Yeoh, {Allen E.J.} and Kjeld Schmiegelow and Yang, {Jun J.}",
note = "Funding Information: We acknowledge the critical input of members of the Clinical Pharmacogenetics Implementation Consortium (CPIC) of the Pharmacogenomics Research Network (PGRN), and U24HG010135, R01GM118578, and P50GM115279. and the PharmVar TPMT and NUDT15 expert panels especially Andrea Gaedigk, PhD. This work is also supported by the Robert Bosch Foundation, Stuttgart, Germany. Funding Information: This guideline is funded by the National Institutes of Health (CPIC (R24GM115264 and U24HG010135) and PharmGKB (R24GM61374, R01GM118578, and P50GM115279)). Funding Information: This guideline is funded by the National Institutes of Health (CPIC (R24GM115264 and U24HG010135) and PharmGKB (R24GM61374, R01GM118578, and P50GM115279)). We acknowledge the critical input of members of the Clinical Pharmacogenetics Implementation Consortium (CPIC) of the Pharmacogenomics Research Network (PGRN), and U24HG010135, R01GM118578, and P50GM115279. and the PharmVar TPMT and NUDT15 expert panels especially Andrea Gaedigk, PhD. This work is also supported by the Robert Bosch Foundation, Stuttgart, Germany. Publisher Copyright: {\textcopyright} 2018 The Authors Clinical Pharmacology & Therapeutics {\textcopyright} 2018 American Society for Clinical Pharmacology and Therapeutics",
year = "2019",
month = may,
doi = "10.1002/cpt.1304",
language = "English (US)",
volume = "105",
pages = "1095--1105",
journal = "Clinical pharmacology and therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "5",
}