Clinical features in T-cell vs. natural killer-cell variants of large granular lymphocyte leukemia

Michelle A. Neben, William G. Morice, Ayalew Tefferi

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Objective: Standard clinical and laboratory evaluations and novel laboratory techniques were used to identify patients with T-cell large granular lymphocyte leukemia (LGLL) and those with natural killer-cell variants of LGLL for comprehensive clinical evaluation. Methods: We used bone marrow histologic analysis, immunophenotypic markers of clonality, and T-cell-receptor gene rearrangement studies to identify patients. Results: The study identified 44 patients with T-cell LGLL and 14 with natural killer-cell LGLL. The two disorders were similar in sex and age distribution of patients; peripheral blood lymphocyte, neutrophil, and platelet counts; and incidence of rheumatoid arthritis. Among the two groups, patients with the T-cell LGLL presented with significantly lower hemoglobin concentrations (P < 0.04) and a higher frequency of palpable splenomegaly (P < 0.01). Conclusion: Overall disease progression and response to immunosuppressive therapy are similar between T-cell and natural killer-cell variants of LGLL.

Original languageEnglish (US)
Pages (from-to)263-265
Number of pages3
JournalEuropean Journal of Haematology
Issue number4
StatePublished - Oct 1 2003


  • Immunophenotype
  • Killing inhibitory receptor
  • Large granular lymphocyte
  • Natural killer cell
  • T-cell

ASJC Scopus subject areas

  • Hematology


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