TY - JOUR
T1 - Clinical diagnostic testing for human cytomegalovirus infections
AU - Razonable, Raymund R.
AU - Inoue, Naoki
AU - Pinninti, Swetha G.
AU - Boppana, Suresh B.
AU - Lazzarotto, Tiziana
AU - Gabrielli, Liliana
AU - Simonazzi, Giuliana
AU - Pellett, Philip E.
AU - Schmid, D. Scott
N1 - Funding Information:
Financial support. This work was supported by Ministry of Health, Labor, and Welfare, Japan and the Agency for Medical Research and Development, Japan (grant numbers H20-Kodomo-007, H23-Jisedai-Ippan-001, H25-Jisedai-Shitei-003, 15gk0110003h0103, 16gk0110 021h0001, 17gk0110021h0002, and 18gk0110021h0003 to N. I. for Research on Child Development and Diseases). S. G. P. and S. B. B. were supported by National Institute on Deafness and Other Communication Disorders grants to S. B. B. (N01 DC50008, HHS-N-263-2012-00010-C).
Funding Information:
Potential conflicts of interest. S. B. B. serves as a member of the CMV Vaccine Advisory Committees of Merck and Sanofi. R. R. R. reports grants from Roche and Novartis outside the submitted work. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
Funding Information:
What follows is a description of strategies for prevention, diagnosis, and monitoring of HCMV infections, based on presentations made during the session on HCMV Diagnostics at a September 2018 conference Cytomegalovirus Infection: Advancing Strategies for Prevention and Treatment, which was sponsored by the National Institutes of Allergy and Infectious
Funding Information:
Supplement sponsorship. This supplement was sponsored by NIAID and NICHD.
Publisher Copyright:
© 2020 Oxford University Press. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Human cytomegalovirus (HCMV) infections are among the most common complications arising in transplant patients, elevating the risk of various complications including loss of graft and death. HCMV infections are also responsible for more congenital infections worldwide than any other agent. Congenital HCMV (cCMV) infections are the leading nongenetic cause of sensorineural hearing loss and a source of significant neurological disabilities in children. While there is overlap in the clinical and laboratory approaches to diagnosis of HCMV infections in these settings, the management, follow-up, treatment, and diagnostic strategies differ considerably. As yet, no country has implemented a universal screening program for cCMV. Here, we summarize the issues, limitations, and application of diagnostic strategies for transplant recipients and congenital infection, including examples of screening programs for congenital HCMV that have been implemented at several centers in Japan, Italy, and the United States.
AB - Human cytomegalovirus (HCMV) infections are among the most common complications arising in transplant patients, elevating the risk of various complications including loss of graft and death. HCMV infections are also responsible for more congenital infections worldwide than any other agent. Congenital HCMV (cCMV) infections are the leading nongenetic cause of sensorineural hearing loss and a source of significant neurological disabilities in children. While there is overlap in the clinical and laboratory approaches to diagnosis of HCMV infections in these settings, the management, follow-up, treatment, and diagnostic strategies differ considerably. As yet, no country has implemented a universal screening program for cCMV. Here, we summarize the issues, limitations, and application of diagnostic strategies for transplant recipients and congenital infection, including examples of screening programs for congenital HCMV that have been implemented at several centers in Japan, Italy, and the United States.
KW - Congenital infection
KW - Diagnosis
KW - Human cytomegalovirus
KW - Pregnancy
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U2 - 10.1093/INFDIS/JIZ601
DO - 10.1093/INFDIS/JIZ601
M3 - Article
C2 - 32134488
AN - SCOPUS:85081943978
SN - 0022-1899
VL - 221
SP - S74-S85
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
ER -