Clinical characteristics of a group of adults with nodular lymphoid hyperplasia: A single center experience

Alberta Rubio-Tapia, Jorge Hernández-Calleros, Sagrario Trinidad-Hernández, Luis Uscanga

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Aim: To describe the clinical and histological characteristics of a group of adults with small-bowel nodular lymphoid hyperplasia (NLH). Methods: Patients were searched for five years in pathology records of our institution. The biopsy material was reassessed using strict histopathological criteria. Clinical data were obtained from medical records. Results: Small-bowel NLH was diagnosed in 18 cases. The female : male ratio was 2: 1. The most frequent symptoms were diarrhea (72%), involuntary weight loss (72%) and abdominal pain (61%). Nine patients (50%) had immunodeficiency. Small-bowel bacterial overgrowth was found in three (17%) cases. At small-bowel NLH diagnosis, three (17%) had associated lymphoma: two intestinal and one extra-intestinal lymphomas. In two patients with villous atrophy and anti-endomysial antibodies the diagnosis of celiac disease was established. Giardia lamblia infection was found in only one patient with hypogammaglobulinemia (Herman's syndrome). Conclusions: NLH is uncommon in adult patients. Associated d iseases are immunodeficiency and lymphoid tissue malignancies.

Original languageEnglish (US)
Pages (from-to)1945-1948
Number of pages4
JournalWorld journal of gastroenterology
Issue number12
StatePublished - Mar 28 2006


  • Hypogamma-globulinemia
  • Lymphoma
  • Nodular lymphoid hyperplasia

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Clinical characteristics of a group of adults with nodular lymphoid hyperplasia: A single center experience'. Together they form a unique fingerprint.

Cite this