Cleavage of a specific bond in troponin C by thrombin

P. C. Leavis, S. Rosenfeld, R. C. Lu

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Limited proteolysis of rabbit skeletal troponin C with bovine thrombin yielded two fragments, TH1 (Mr = 11 000) containing Ca2+ binding regions I-III and TH2 (Mr = 6000) containing region IV. Determination of the partial sequences of the fragments established the site of cleavage at Arg120-Ala121. Secondary cleavage by thrombin at other arginyl or lysyl residues in troponin C was ruled out by the sequence data and by the amino acid compositions of the two fragments.

Original languageEnglish (US)
Pages (from-to)281-286
Number of pages6
JournalBBA - Protein Structure
Issue number2
StatePublished - Aug 21 1978

ASJC Scopus subject areas

  • General Medicine


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