@article{868af6124fff40b4bb2501d1d268202d,
title = "Classification, risk stratification and response assessment in myelodysplastic syndromes/neoplasms (MDS): A state-of-the-art report on behalf of the International Consortium for MDS (icMDS)",
abstract = "The guidelines for classification, prognostication, and response assessment of myelodysplastic syndromes/neoplasms (MDS) have all recently been updated. In this report on behalf of the International Consortium for MDS (icMDS) we summarize these developments. We first critically examine the updated World Health Organization (WHO) classification and the International Consensus Classification (ICC) of MDS. We then compare traditional and molecularly based risk MDS risk assessment tools. Lastly, we discuss limitations of criteria in measuring therapeutic benefit and highlight how the International Working Group (IWG) 2018 and 2023 response criteria addressed these deficiencies and are endorsed by the icMDS. We also address the importance of patient centered care by discussing the value of quality-of-life assessment. We hope that the reader of this review will have a better understanding of how to classify MDS, predict clinical outcomes and evaluate therapeutic outcomes.",
keywords = "Diagnostic criteria, IPSS-M, MDS, Myelodysplastic syndrome, Novel therapies, Risk classification",
author = "Maximilian Stahl and Bewersdorf, {Jan Philipp} and Zhuoer Xie and Porta, {Matteo Giovanni Della} and Rami Komrokji and Xu, {Mina L.} and Omar Abdel-Wahab and Justin Taylor and Steensma, {David P.} and Starczynowski, {Daniel T.} and Sekeres, {Mikkael A.} and Guillermo Sanz and Sallman, {David A.} and Roboz, {Gail J.} and Uwe Platzbecker and Patnaik, {Mrinal M.} and Eric Padron and Olatoyosi Odenike and Nimer, {Stephen D.} and Aziz Nazha and Ravi Majeti and Sanam Loghavi and Little, {Richard F.} and List, {Alan F.} and Kim, {Tae Kon} and Hourigan, {Christopher S.} and Hasserjian, {Robert P.} and Stephanie Halene and Griffiths, {Elizabeth A.} and Gore, {Steven D.} and Peter Greenberg and Figueroa, {Maria E.} and Pierre Fenaux and Fabio Efficace and DeZern, {Amy E.} and Daver, {Naval G.} and Churpek, {Jane E.} and Carraway, {Hetty E.} and Rena Buckstein and Brunner, {Andrew M.} and Jacqueline Boultwood and Uma Borate and Rafael Bejar and Bennett, {John M.} and Wei, {Andrew H.} and Valeria Santini and Savona, {Michael R.} and Zeidan, {Amer M.}",
note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",
year = "2023",
month = nov,
doi = "10.1016/j.blre.2023.101128",
language = "English (US)",
volume = "62",
journal = "Blood Reviews",
issn = "0268-960X",
publisher = "Churchill Livingstone",
}