Circulating osteogenic cells: Implications for injury, repair, and regeneration

Robert J. Pignolo, Moustapha Kassem

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


The aim of this review is to provide a critical reading of recent literature pertaining to the presence of circulating, fluid-phase osteoblastic cells and their possible contribution to bone formation. We have termed this group of cells collectively as circulating osteogenic precursor (COP) cells. We present evidence for their existence, methods used for their isolation and identification, possible physiological and pathophysiological roles, cellular origins, and possible mechanisms for their migration to target tissues.

Original languageEnglish (US)
Pages (from-to)1685-1693
Number of pages9
JournalJournal of Bone and Mineral Research
Issue number8
StatePublished - Aug 2011


  • blood
  • circulating osteogenic precursor cells
  • fracture
  • heterotopic ossification
  • mesenchymal stem cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine


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