Circulating natriuretic peptide concentrations in patients with end-stage renal disease: Role of brain natriuretic peptide as a biomarker for ventricular remodeling

Alessandro Cataliotti, Lorenzo S. Malatino, Michihisa Jougasaki, Carmine Zoccali, Pietro Castellino, Giuseppe Giacone, Ignazio Bellanuova, Rocco Tripepi, Giuseppe Seminara, Saverio Parlongo, Benedetta Stancanelli, Grazia Bonanno, Pasquale Fatuzzo, Francesco Rapisarda, Paola Belluardo, Salvatore S. Signorelli, Denise M. Heublein, John G. Lainchbury, Hanna K. Leskinen, Kent R. BaileyMargaret M. Redfield, John C. Burnett

Research output: Contribution to journalArticlepeer-review

167 Scopus citations


Objectives: To determine levels of natriuretic peptides (NPs) in patients with end-stage renal disease (ESRD) and to examine the relationship of these cardiovascular peptides to left ventricular hypertrophy (LVH) and to cardiac mortality. Patients and Methods: One hundred twelve dialysis patients without clinical evidence of congestive heart failure underwent plasma measurement of NP concentrations and echocardiographic investigation for left ventricular mass index (LVMI). Results: Plasma atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations correlated positively with LVMI and inversely with left ventricular ejection fraction, whereas C-type NP and Dendroaspis NP levels did not correlate with LVMI. In dialysis patients with LVH (LVMI > 125 g/m2), plasma ANP and BNP concentrations were increased compared with those in dialysis patients without LVH (both P<.001). In a subset of 15 dialysis patients without LVH or other concomitant diseases, plasma BNP concentrations were not significantly increased compared with those in 35 controls (mean ± SD, 20.1±13.4 vs 13.5±9.6 pg/mL; P=.06), demonstrating that the BNP concentration was not increased by renal dysfunction alone. Furthermore, the BNP level was significantly higher in the 16 patients who died from cardiovascular causes compared with survivors (mean±SD, 129±13 vs 57±7 pg/mL; P<.003) and was significantly associated with greater risk of cardiovascular death in Cox regression analysis (P<.001), as was the ANP level (P=.002). Conclusions: Elevation of the plasma BNP concentration is more specifically related to LVH compared with the other NP levels in patients with ESRD independent of congestive heart failure. Thus, BNP serves as an important plasma biomarker for ventricular hypertrophy in dialysis patients with ESRD.

Original languageEnglish (US)
Pages (from-to)1111-1119
Number of pages9
JournalMayo Clinic proceedings
Issue number11
StatePublished - 2001


  • ANP = atrial natriuretic peptide
  • AUC = area under the curve
  • BNP = brain natriuretic peptide
  • CAD = coronary artery disease
  • CHF = congestive heart failure
  • CNP = C-type natriuretic peptide
  • DNP = Dendroaspis natriuretic peptide
  • DNP-LI = DNP-like immunoreactivity
  • ESRD = end-stage renal disease
  • IVST = intraventricular septum thickness
  • Kt/V = fractional urea clearance rate
  • LVD = left ventricular systolic dysfunction
  • LVEF = left ventricular ejection fraction
  • LVH = left ventricular hypertrophy
  • LVMI = left ventricular mass index
  • MI = myocardial infarction
  • NP = natriuretic peptide
  • PWT = posterior wall thickness
  • ROC = receiver operating characteristic

ASJC Scopus subject areas

  • Medicine(all)


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