Chronic Lymphocytic Leukemia: An Unusual Cause of Upper Gastrointestinal Hemorrhage

Douglas O. Faigel, David J. Vaughn, Emma E. Furth, David C. Metz

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


In contrast to the acute leukemias, chronic lymphocytic leukemia (CLL) is a hematological malignancy with a generally good prognosis. Gastrointestinal (GI) involvement with CLL is unusual, and GI complications generally occur after malignant transformation to diffuse large cell lymphoma (Richter's syndrome). We present a case of CLL directly infiltrating the gastroesophageal junction resulting in upper GI hemorrhage. This is only the second such case in the literature. We emphasize the consideration of direct leukemic infiltration in addition to Richter's syndrome in the differential diagnosis of GI bleeding in patients with CLL. Whereas the prognosis of Richter's syndrome is poor, CLL involvement of the GI tract may respond to treatment with chemo‐ or radiotherapy.

Original languageEnglish (US)
Pages (from-to)635-637
Number of pages3
JournalThe American Journal of Gastroenterology
Issue number4
StatePublished - Apr 1995

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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