Chronic divalproex sodium to attenuate agitation and clinical progression of Alzheimer disease

Pierre N. Tariot, Lon S. Schneider, Jeffrey Cummings, Ronald G. Thomas, Rema Raman, Laura J. Jakimovich, Rebekah Loy, Barbara Bartocci, Adam Fleisher, M. Saleem Ismail, Anton Porsteinsson, Michael Weiner, Clifford R. Jack, Leon Thal, Paul S. Aisen

Research output: Contribution to journalArticlepeer-review

126 Scopus citations


Context: Agitation and psychosis are common in Alzheimer disease and cause considerable morbidity. We attempted to delay or to prevent agitation and psychosis with the use of divalproex sodium (valproate). Objective: To determine whether treatment with valproate could delay or prevent emergence of agitation or psychosis. Design, Setting, and Patients: A multicenter, randomized, double-blind, placebo-controlled trial of flexibledose valproate in 313 (of 513 screened) individuals with moderate Alzheimer disease who had not yet experienced agitation or psychosis. The study was conducted from November 1, 2005, through March 31, 2009, at 46 sites in the United States. Intervention: Participants were randomly assigned to valproate treatment at a target dose of 10 to 12 mg per kilogram of body weight per day or identical-appearing placebo for 24 months followed by a 2-month period of single-blind placebo treatment. Main Outcome Measure: Time to emergence of clinically significant agitation or psychosis. Results: A total of 122 participants (59 receiving valproate and 63 receiving placebo) completed 24 months of treatment while taking study medication; 42 (27 receiving valproate and 15 receiving placebo) reached 24 months having discontinued study medication; 150 reached month 26. There was no difference between groups in time to emergence of agitation or psychosis (Cox proportional hazard ratio, 0.96; P=.88). There was no difference between groups in change on any secondary outcome. The valproate group had higher rates of somnolence, gait disturbance, tremor, diarrhea, and weakness. Eighty-eight participants underwent magnetic resonance imaging scans at baseline and 12 months; the valproate group showed greater loss in hippocampal and whole-brain volume, accompanied by greater ventricular expansion (P<.001). Conclusion: Valproate treatment did not delay emergence of agitation or psychosis or slow cognitive or functional decline in patients with moderate Alzheimer disease and was associated with significant toxic effects. Trial Registration: Identifier: NCT00071721.

Original languageEnglish (US)
Pages (from-to)853-861
Number of pages9
JournalArchives of General Psychiatry
Issue number8
StatePublished - Aug 2011

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health


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