Chromosomes at Work: Organization of Chromosome Territories in the Interphase Nucleus

Andrew J. Fritz, A. Rasim Barutcu, Lori Martin-Buley, André J. Van Wijnen, Sayyed K. Zaidi, Anthony N. Imbalzano, Jane B. Lian, Janet L. Stein, Gary S. Stein

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The organization of interphase chromosomes in chromosome territories (CTs) was first proposed more than one hundred years ago. The introduction of increasingly sophisticated microscopic and molecular techniques, now provide complementary strategies for studying CTs in greater depth than ever before. Here we provide an overview of these strategies and how they are being used to elucidate CT interactions and the role of these dynamically regulated, nuclear-structure building blocks in directly supporting nuclear function in a physiologically responsive manner.

Original languageEnglish (US)
Pages (from-to)9-19
Number of pages11
JournalJournal of cellular biochemistry
Issue number1
StatePublished - Jan 1 2016


  • CTs

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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