William C. Palmer, Denise M. Harnois

Research output: Chapter in Book/Report/Conference proceedingChapter


Cholangiocarcinoma (CCA), an uncommon biliary adenocarcinoma, can be divided into intrahepatic and extrahepatic types. Intrahepatic CCA (IH-CCA) comprises approximately 25 % of all CCAs, and can be characterized as peripheral mass-forming or central periductal infiltrating tumors. Most patients do not possess known risk factors, but a strong association with cirrhosis has been documented. The clinical presentation of IH-CCA can be nonspecific even in the late stages of the disease. Management combines surgical resection, systemic chemotherapy, and targeted radiation therapy. Surgically unresectable disease is incurable with current treatment options. Enrollment in clinical trials and referral to tertiary centers are recommended for patients with unresectable or recurrent disease.

Original languageEnglish (US)
Title of host publicationComplications of Cirrhosis
Subtitle of host publicationEvaluation and Management
PublisherSpringer International Publishing
Number of pages9
ISBN (Electronic)9783319136141
ISBN (Print)9783319136134
StatePublished - Jan 1 2015


  • Bile duct cancer
  • Cirrhosis
  • Liver cancer
  • Liver transplantation

ASJC Scopus subject areas

  • General Medicine


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