TY - JOUR
T1 - Characterizing white matter tract degeneration in syndromic variants of Alzheimer's disease
T2 - A diffusion tensor imaging study
AU - Madhavan, Ajay
AU - Schwarz, Christopher G.
AU - Duffy, Joseph R.
AU - Strand, Edythe A.
AU - Machulda, Mary M.
AU - Drubach, Daniel A.
AU - Kantarci, Kejal
AU - Przybelski, Scott A.
AU - Reid, Robert I.
AU - Senjem, Matthew L.
AU - Gunter, Jeffrey L.
AU - Apostolova, Liana G.
AU - Lowe, Val J.
AU - Petersen, Ronald C.
AU - Jack, Clifford R.
AU - Josephs, Keith A.
AU - Whitwell, Jennifer L.
N1 - Publisher Copyright:
© 2016 - IOS Press and the authors. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Background: Different clinical syndromes can arise from Alzheimer's disease (AD) neuropathology, including dementia of the Alzheimer's type (DAT), logopenic primary progressive aphasia (lvPPA), and posterior cortical atrophy (PCA). Objective: To assess similarities and differences in patterns of white matter tract degeneration across these syndromic variants of AD. Methods: Sixty-four subjects (22 DAT, 24 lvPPA, and 18 PCA) that had diffusion tensor imaging and showed amyloid deposition on PET were assessed in this case-control study. A whole-brain voxel-based analysis was performed to assess differences in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity across groups. Results: All three groups showed overlapping diffusion abnormalities in a network of tracts, including fornix, corpus callosum, posterior thalamic radiations, superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and uncinate fasciculus. Subtle regional differences were also observed across groups, with DAT particularly associated with degeneration of fornix and cingulum, lvPPA with left inferior fronto-occipital fasciculus and uncinate fasciculus, and PCA with posterior thalamic radiations, superior longitudinal fasciculus, posterior cingulate, and splenium of the corpus callosum. Conclusion: These findings show that while each AD phenotype is associated with degeneration of a specific structural network of white matter tracts, striking spatial overlap exists among the three network patterns that may be related to AD pathology.
AB - Background: Different clinical syndromes can arise from Alzheimer's disease (AD) neuropathology, including dementia of the Alzheimer's type (DAT), logopenic primary progressive aphasia (lvPPA), and posterior cortical atrophy (PCA). Objective: To assess similarities and differences in patterns of white matter tract degeneration across these syndromic variants of AD. Methods: Sixty-four subjects (22 DAT, 24 lvPPA, and 18 PCA) that had diffusion tensor imaging and showed amyloid deposition on PET were assessed in this case-control study. A whole-brain voxel-based analysis was performed to assess differences in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity across groups. Results: All three groups showed overlapping diffusion abnormalities in a network of tracts, including fornix, corpus callosum, posterior thalamic radiations, superior longitudinal fasciculus, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, and uncinate fasciculus. Subtle regional differences were also observed across groups, with DAT particularly associated with degeneration of fornix and cingulum, lvPPA with left inferior fronto-occipital fasciculus and uncinate fasciculus, and PCA with posterior thalamic radiations, superior longitudinal fasciculus, posterior cingulate, and splenium of the corpus callosum. Conclusion: These findings show that while each AD phenotype is associated with degeneration of a specific structural network of white matter tracts, striking spatial overlap exists among the three network patterns that may be related to AD pathology.
KW - Alzheimer's disease
KW - Diffusion tensor imaging
KW - Logopenic
KW - Posterior cortical atrophy
KW - White matter
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U2 - 10.3233/JAD-150502
DO - 10.3233/JAD-150502
M3 - Article
C2 - 26484918
AN - SCOPUS:84949936462
SN - 1387-2877
VL - 49
SP - 633
EP - 643
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 3
ER -