@article{6925a65dc9334b87917026ec41261110,
title = "Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants",
abstract = "The transferability and clinical value of genetic risk scores (GRSs) across populations remain limited due to an imbalance in genetic studies across ancestrally diverse populations. Here we conducted a multi-ancestry genome-wide association study of 156,319 prostate cancer cases and 788,443 controls of European, African, Asian and Hispanic men, reflecting a 57% increase in the number of non-European cases over previous prostate cancer genome-wide association studies. We identified 187 novel risk variants for prostate cancer, increasing the total number of risk variants to 451. An externally replicated multi-ancestry GRS was associated with risk that ranged from 1.8 (per standard deviation) in African ancestry men to 2.2 in European ancestry men. The GRS was associated with a greater risk of aggressive versus non-aggressive disease in men of African ancestry (P = 0.03). Our study presents novel prostate cancer susceptibility loci and a GRS with effective risk stratification across ancestry groups.",
author = "{The Biobank Japan Project} and Anqi Wang and Jiayi Shen and Rodriguez, {Alex A.} and Saunders, {Edward J.} and Fei Chen and Rohini Janivara and Darst, {Burcu F.} and Xin Sheng and Yili Xu and Chou, {Alisha J.} and Sara Benlloch and Tokhir Dadaev and Brook, {Mark N.} and Anna Plym and Ali Sahimi and Hoffman, {Thomas J.} and Atushi Takahashi and Koichi Matsuda and Yukihide Momozawa and Masashi Fujita and Triin Laisk and J{\'e}ssica Figuer{\^e}do and Kenneth Muir and Shuji Ito and Xiaoxi Liu and Yuji Yamanashi and Yoichi Furukawa and Takayuki Morisaki and Yoshinori Murakami and Kaori Muto and Akiko Nagai and Wataru Obara and Ken Yamaji and Kazuhisa Takahashi and Satoshi Asai and Yasuo Takahashi and Takao Suzuki and Nobuaki Sinozaki and Hiroki Yamaguchi and Shiro Minami and Shigeo Murayama and Kozo Yoshimori and Satoshi Nagayama and Daisuke Obata and Masahiko Higashiyama and Akihide Masumoto and Yukihiro Koretsune and Yuji Uchio and Thibodeau, {Stephen N.} and Schaid, {Daniel J.}",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2023",
month = dec,
doi = "10.1038/s41588-023-01534-4",
language = "English (US)",
volume = "55",
pages = "2065--2074",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "12",
}