Characteristics of luteinizing hormone secretion in younger versus older premenopausal women

D. W. Matt, S. W. Kauma, S. M. Pincus, J. D. Veldhuis, W. S. Evans

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


OBJECTIVES: The objectives of this study were to document specific attributes of pulsatile luteinizing hormone secretion in middle-aged women before discernible alterations in their menstrual cycles and to compare the results to corresponding data obtained in younger women. STUDY DESIGN: After documenting normal cycle length, biphasic basal body temperatures, and normal midluteal progesterone in younger and middle-aged women during an initial cycle, daily blood samples and samples withdrawn at 10-minute intervals for 8 hours during the midfollicular phase were obtained during a subsequent cycle. RESULTS: Assessment of luteinizing hormone pulses with the pulse detection algorithm Cluster demonstrated a prolonged interpulse interval and increased pulse width in the older women. Assessment of luteinizing hormone secretory bursts and half-life with the deconvolution analysis procedure demonstrated a prolonged interburst interval and half-life in the older women. Appraisal of approximate entropy revealed greater orderliness of luteinizing hormone release in the older women. CONCLUSIONS: Middle-aged women exhibit alterations in hypothalamic-pituitary function that may account in part for age-related changes in reproductive potential.

Original languageEnglish (US)
Pages (from-to)504-510
Number of pages7
JournalAmerican journal of obstetrics and gynecology
Issue number3
StatePublished - 1998


  • Aging
  • Fecundity
  • Luteinizing hormone secretion

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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