Changes in Therapy Are Not Associated With Increased Remission in Patients With Crohn’s Disease of the Pouch

Maia Kayal; Parakkal Deepak; Poonam Beniwal-Patel; Laura Raffals; Marla Dubinsky; Shannon Chang; Peter D.R. Higgins; Yue Jiang; Raymond K. Cross; Millie D. Long; Hans H. Herfarth; Edward L. Barnes

doi:10.14309/ajg.0000000000002599

Changes in Therapy Are Not Associated With Increased Remission in Patients With Crohn’s Disease of the Pouch

Maia Kayal, Parakkal Deepak, Poonam Beniwal-Patel, Laura Raffals, Marla Dubinsky, Shannon Chang, Peter D.R. Higgins, Yue Jiang, Raymond K. Cross, Millie D. Long, Hans H. Herfarth, Edward L. Barnes

Gastroenterology and Hepatology

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: There is a paucity of data on the real-world effectiveness of therapies in patients with Crohn’s disease of the pouch. METHODS: This was a prospective multicenter study evaluating the primary outcome of remission at 12 months of therapy for Crohn’s disease of the pouch. RESULTS: One hundred thirty-four patients were enrolled. Among the 77 patients with symptoms at baseline, 35 (46.7%) achieved remission at 12 months. Of them, 12 (34.3%) changed therapy. There was no significant association between therapy patterns and remission status. DISCUSSION: Approximately 50% with symptoms at enrollment achieved clinical remission at 12 months, most of whom did so without a change in therapy.

Original language	English (US)
Pages (from-to)	584-587
Number of pages	4
Journal	American Journal of Gastroenterology
Volume	119
Issue number	3
DOIs	https://doi.org/10.14309/ajg.0000000000002599
State	Published - Mar 1 2024

Keywords

colectomy
ileal pouch anal anastomosis
therapy
ulcerative colitis

ASJC Scopus subject areas

Hepatology
Gastroenterology

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Kayal, M., Deepak, P., Beniwal-Patel, P., Raffals, L., Dubinsky, M., Chang, S., Higgins, P. D. R., Jiang, Y., Cross, R. K., Long, M. D., Herfarth, H. H., & Barnes, E. L. (2024). Changes in Therapy Are Not Associated With Increased Remission in Patients With Crohn’s Disease of the Pouch. American Journal of Gastroenterology, 119(3), 584-587. https://doi.org/10.14309/ajg.0000000000002599

Kayal, M, Deepak, P, Beniwal-Patel, P, Raffals, L, Dubinsky, M, Chang, S, Higgins, PDR, Jiang, Y, Cross, RK, Long, MD, Herfarth, HH & Barnes, EL 2024, 'Changes in Therapy Are Not Associated With Increased Remission in Patients With Crohn’s Disease of the Pouch', American Journal of Gastroenterology, vol. 119, no. 3, pp. 584-587. https://doi.org/10.14309/ajg.0000000000002599

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abstract = "INTRODUCTION: There is a paucity of data on the real-world effectiveness of therapies in patients with Crohn{\textquoteright}s disease of the pouch. METHODS: This was a prospective multicenter study evaluating the primary outcome of remission at 12 months of therapy for Crohn{\textquoteright}s disease of the pouch. RESULTS: One hundred thirty-four patients were enrolled. Among the 77 patients with symptoms at baseline, 35 (46.7%) achieved remission at 12 months. Of them, 12 (34.3%) changed therapy. There was no significant association between therapy patterns and remission status. DISCUSSION: Approximately 50% with symptoms at enrollment achieved clinical remission at 12 months, most of whom did so without a change in therapy.",

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author = "Maia Kayal and Parakkal Deepak and Poonam Beniwal-Patel and Laura Raffals and Marla Dubinsky and Shannon Chang and Higgins, {Peter D.R.} and Yue Jiang and Cross, {Raymond K.} and Long, {Millie D.} and Herfarth, {Hans H.} and Barnes, {Edward L.}",

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AU - Kayal, Maia

AU - Deepak, Parakkal

AU - Beniwal-Patel, Poonam

AU - Raffals, Laura

AU - Dubinsky, Marla

AU - Chang, Shannon

AU - Higgins, Peter D.R.

AU - Jiang, Yue

AU - Cross, Raymond K.

AU - Long, Millie D.

AU - Herfarth, Hans H.

AU - Barnes, Edward L.

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AB - INTRODUCTION: There is a paucity of data on the real-world effectiveness of therapies in patients with Crohn’s disease of the pouch. METHODS: This was a prospective multicenter study evaluating the primary outcome of remission at 12 months of therapy for Crohn’s disease of the pouch. RESULTS: One hundred thirty-four patients were enrolled. Among the 77 patients with symptoms at baseline, 35 (46.7%) achieved remission at 12 months. Of them, 12 (34.3%) changed therapy. There was no significant association between therapy patterns and remission status. DISCUSSION: Approximately 50% with symptoms at enrollment achieved clinical remission at 12 months, most of whom did so without a change in therapy.

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KW - ileal pouch anal anastomosis

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KW - ulcerative colitis

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Changes in Therapy Are Not Associated With Increased Remission in Patients With Crohn’s Disease of the Pouch

Abstract

Keywords

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