Challenges of biological valve development

Daniel B. Spoon, Brandon J. Tefft, Amir Lerman, Robert D. Simari

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


The development of mechanical and bioprosthetic valvular prostheses have enhanced the survival and quality of life for countless patients. Despite the benefits provided by prosthetic valves, there are still significant limitations to those currently available. The goal biological valve tissue engineering strives to overcome is the limitations of the currently available prosthetic valves. This review will outline some of the past and present approaches that have been and are being taken in an attempt to create the ideal replacement valve. In addition, some of the challenges associated with this task will be highlighted.

Original languageEnglish (US)
Pages (from-to)319-334
Number of pages16
JournalInterventional Cardiology (London)
Issue number3
StatePublished - Jun 2013


  • aortic valve
  • bioreactor
  • decellularization
  • heart valve
  • pulmonic valve
  • recellularization
  • scaffold
  • stem cell
  • tissue engineering

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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