Challenges in the Use of Targeted Therapies in Non-Small Cell Lung Cancer

Joel Rivera-Concepcion, Dipesh Uprety, Alex A. Adjei

Research output: Contribution to journalReview articlepeer-review


Precision oncology has fundamentally changed how we diagnose and treat cancer. In recent years, there has been a significant change in the management of patients with oncogene-addicted advanced-stage non-small cell lung cancer (NSCLC). Increasing amounts of identifiable oncogene drivers have led to the development of molecularly targeted drugs. Undoubtedly, the future of thoracic oncology is shifting toward increased molecular testing and the use of targeted therapies. For the most part, these novel drugs have proven to be safe and effective. As with all great innovations, targeted therapies pose unique challenges. Drug toxicities, resistance, access, and costs are some of the expected obstacles that will need to be addressed. This review highlights some of the major challenges in the use of targeted therapies in NSCLC and provides guidance for the future strategies.

Original languageEnglish (US)
Pages (from-to)315-329
Number of pages15
JournalCancer Research and Treatment
Issue number2
StatePublished - Apr 2022


  • Challenges
  • Cost
  • Drug resistance
  • Lung neoplasms
  • Non-small cell lung carcinoma
  • Targeted therapy
  • Toxicity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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