Cerebrovascular response time to a breath-holding challenge

Georg Gahn, S. Hallmeyer-Elgner, U. Becker, K. M. Barrett, R. H. Ackermann

Research output: Contribution to journalArticlepeer-review


Background: To evaluate the timecourse of cerebrovascular reserve response to breath-holding. Patients and methods: Using simultaneous bilateral transcranial Doppler (TCD) recordings from the MCA during a breath-holding challenge, we measured the time interval between baseline and peak blood flow velocity values in 25 patients with critical unilateral internal carotid artery (ICA) stenosis (> 85% lumen diameter reduction), in 9 patients with a non-critical (70-85%) ICA-stenosis and in 27 normal controls. Results: Normal controls and patients with non-critical stenosis reached peak MCA velocities on both sides almost simultaneously. For the patients with critical stenosis the peak response time ipsilateral to the stenosis was delayed 2.40 ± 3.43 sec compared to the opposite side. This delay resolved after carotid endarterectomy. Conclusions: In response to a breath-holding challenge unilateral critical ICA stenosis is associated with a significant ipsilateral prolongation of the rise time from baseline to peak MCA velocity.

Original languageEnglish (US)
Pages (from-to)181-184
Number of pages4
JournalVasa - Journal of Vascular Diseases
Issue number3
StatePublished - Aug 2007


  • Carotid artery stenosis
  • Carotid endarterectomy
  • Cerebrovascular reserve
  • Transcranial doppler

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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