TY - JOUR
T1 - Cerebral Venous Sinus Thrombosis in Women
T2 - Subgroup Analysis of the VENOST Study
AU - Uluduz, Derya
AU - Sahin, Sevki
AU - Duman, Taskin
AU - Ozturk, Serefnur
AU - Yayla, Vildan
AU - Afsar, Nazire
AU - Uzuner, Nevzat
AU - Midi, Ipek
AU - Cinar, Nilgun
AU - Sungur, Mehmet Ali
AU - Domac, Fusun Mayda
AU - Ince, Birsen
AU - Goksan, Baki
AU - Misirli, Cemile Handan
AU - Bakar, Mustafa
AU - Kozak, Hasan Huseyin
AU - Colakoglu, Sena
AU - Karahan, Ali Yavuz
AU - Goksu, Eylem Ozaydin
AU - Ozdag, Fatih
AU - Senol, Mehmet Guney
AU - Yurekli, Vedat Ali
AU - Aluclu, Ufuk
AU - Demir, Serkan
AU - Kucukoglu, Hayriye
AU - Oruc, Serdar
AU - Yesilot, Nilufer
AU - Kusbeci, Ozge Yimaz
AU - Nazliel, Bijen
AU - Tokuc, Firdevs Ezgi Ucan
AU - Bektas, Hesna
AU - Tascilar, Fatma Nida
AU - Aytac, Emrah
AU - Gokce, Mustafa
AU - Caglayan, Hale Zeynep Batur
AU - Tufekci, Ahmet
AU - Uzuner, Gulnur
AU - Orken, Dilek Necioglu
AU - Yalin, Osman Ozgur
AU - Utku, Uygar
AU - Yilmaz, Arda
AU - Genc, Hamit
AU - Cabalar, Murat
AU - Milanlioglu, Aysel
AU - Ekmekci, Hakan
AU - Zeydan, Burcu
AU - Baybas, Sevim
AU - Kablan, Yuksel
AU - Goksel, Basak Karakurum
AU - Acikgoz, Mustafa
AU - Kurucu, Hatice
AU - Demirci, Seden
AU - Gunes, Taskin
N1 - Publisher Copyright:
© 2020 Derya Uluduz et al.
PY - 2020
Y1 - 2020
N2 - Background. Early diagnosis of cerebral venous sinus thrombosis (CVST) associated with reproductive health-related risk factors (RHRF) including pregnancy, puerperium, and oral contraceptive (OC) use can prevent severe neurological sequelae; thus, the symptoms must be documented in detail for each group. Methods. Out of 1144 patients with CVST, a total of 777 women were enrolled from a multicenter for the study of cerebral venous sinus thrombosis (VENOST). Demographic, biochemical, clinical, and radiological aspects were compared for 324 cases with RHRF and 453 cases without RHRF. Results. The mean age of the RHRF (-) group (43.2 ± 13 years) was significantly higher than of the RHRF (+) group (34±9 years). A previous history of deep venous thrombosis (3%), isolated cavernous sinus involvement (1%), cranial neuropathy (13%), comorbid malignancy (7%), and its disability scores after 12 months (9%) were significantly higher in the RHRF (-) group. The RHRF (+) group consisted of 44% cases of puerperium, 33% cases of OC users and 23% of pregnant women. The mean age was found to be higher in OC users (38±9 years). A previous history of deep venous thrombosis was slightly higher in the pregnancy subgroup (4%). Epileptic seizures were more common in the puerperium group (44%). Conclusion. The results of our study indicate that the risk of CSVT increases parallel to age, OC use, and puerperium period. In addition, when considering the frequency of findings and symptoms, epileptic seizures in the puerperium subgroup of the RHRF (+) group and malignancies in the RHRF (-) group may accompany the CSVT. In daily practice, predicting these risks for the CSVT and early recognition of the symptoms will provide significant benefits to patients.
AB - Background. Early diagnosis of cerebral venous sinus thrombosis (CVST) associated with reproductive health-related risk factors (RHRF) including pregnancy, puerperium, and oral contraceptive (OC) use can prevent severe neurological sequelae; thus, the symptoms must be documented in detail for each group. Methods. Out of 1144 patients with CVST, a total of 777 women were enrolled from a multicenter for the study of cerebral venous sinus thrombosis (VENOST). Demographic, biochemical, clinical, and radiological aspects were compared for 324 cases with RHRF and 453 cases without RHRF. Results. The mean age of the RHRF (-) group (43.2 ± 13 years) was significantly higher than of the RHRF (+) group (34±9 years). A previous history of deep venous thrombosis (3%), isolated cavernous sinus involvement (1%), cranial neuropathy (13%), comorbid malignancy (7%), and its disability scores after 12 months (9%) were significantly higher in the RHRF (-) group. The RHRF (+) group consisted of 44% cases of puerperium, 33% cases of OC users and 23% of pregnant women. The mean age was found to be higher in OC users (38±9 years). A previous history of deep venous thrombosis was slightly higher in the pregnancy subgroup (4%). Epileptic seizures were more common in the puerperium group (44%). Conclusion. The results of our study indicate that the risk of CSVT increases parallel to age, OC use, and puerperium period. In addition, when considering the frequency of findings and symptoms, epileptic seizures in the puerperium subgroup of the RHRF (+) group and malignancies in the RHRF (-) group may accompany the CSVT. In daily practice, predicting these risks for the CSVT and early recognition of the symptoms will provide significant benefits to patients.
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U2 - 10.1155/2020/8610903
DO - 10.1155/2020/8610903
M3 - Article
AN - SCOPUS:85091439977
SN - 2090-8105
VL - 2020
JO - Stroke Research and Treatment
JF - Stroke Research and Treatment
M1 - 8610903
ER -