Cerebral granular cell tumor: Immunohistochemical and electron microscopic study

Dennis W. Dickson, Kinuko I. Suzuki, Ronald Kanner, Stephen Weitz, Dikran S. Horoupian

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


A rare intracerebral granular cell tumor (GCT) was studied by immu-nocytochemical and ultrastructural methods. The tumor was composed of two cell types-filament-rich and granular cells. Granular cells contained PAS-positive, dia-stase-resistant granules that ultrastructurally corresponded to autophagic cytosegre-somes. Glial fibrillary acidic protein, the intermediate filament protein specific for astrocytes, was demonstrated in the filament-rich and, to a lesser extent, in the granular cells. Unlike noncerebral GCT, neither S-100 protein nor vimentin was detected in the tumor cells. On the other hand, both cerebral and noncerebral GCT were labeled immunocytochemically with peanut lectin (Arachis hypogaea). The results suggest that cerebral GCT share some features with noncerebral GCT, but differ in other respects. They further suggest that GCT may be derived from different cell types depending on the tissue of origin, and that cerebral GCT may be derived from astrocytes.

Original languageEnglish (US)
Pages (from-to)304-314
Number of pages11
JournalJournal of Neuropathology and Experimental Neurology
Issue number3
StatePublished - May 1986


  • Electron microscopy
  • Glial fibrillary acidic protein
  • Granular cell tumor
  • Immunocytochemistry
  • Lectins, peanut
  • Myoblastoma, granular cell
  • S-100 protein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience


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