@article{c89bccbb14e048d0a92dbc1dfd7e1d8e,
title = "Cerebellar volume loss in radiologically isolated syndrome",
abstract = "Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC (p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.",
keywords = "Radiologically isolated syndrome, brainstem, cerebellar atrophy, cerebellum, multiple sclerosis, white matter lesions",
author = "George, {Ilena C.} and {El Mendili}, {Mohamed Mounir} and Matilde Inglese and Azevedo, {Christina J.} and Orhun Kantarci and Christine Lebrun and Aksel Siva and Okuda, {Darin T.} and Daniel Pelletier",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the National Institutes of Health (NIH) (National Institute of Neurological Disorders and Stroke R01NS062885 to D.P.), the National Multiple Sclerosis Society (Sylvia Lawry Physician Fellowship Award to I.C.G.), and the Race to Erase MS Foundation (14-003399 to C.J.A.). Funding Information: George Ilena C * Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA El Mendili Mohamed Mounir * Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA Inglese Matilde Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA/Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy/IRCCS Ospedale Policlinico San Martino, Genoa, Italy Azevedo Christina J Department of Neurology, University of Southern California, Los Angeles, CA, USA Kantarci Orhun Mayo Clinic, Rochester, MN, USA Lebrun Christine Service de Neurologie, H{\^o}pital Pasteur 2, Universit{\'e} Nice C{\^o}t{\'e} d{\textquoteright}Azur, Nice, France Siva Axel Department of Neurology, Cerrahpasa School of Medicine, University of Istanbul, Istanbul, Turkey Okuda Darin T UT Southwestern Medical Center, Dallas, TX, USA Pelletier Daniel Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Neuro-Immunology Division and USC Multiple Sclerosis Comprehensive Care Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA Department of Neurology, Keck School of Medicine, University of Southern California, 1540 Alcazar Street, Suite 206, Los Angeles, CA 90033, USA. Daniel.Pelletier@usc.edu * Ilena C George and Mohamed Mounir El Mendili are co-first authors. 10 2019 1352458519887346 21 7 2019 9 10 2019 14 10 2019 {\textcopyright} The Author(s), 2019 2019 SAGE Publications Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC ( p = 0.003 and p = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination. Radiologically isolated syndrome multiple sclerosis cerebellum brainstem cerebellar atrophy white matter lesions National Institutes of Health https://doi.org/10.13039/100000002 R01NS062885 race to erase ms https://doi.org/10.13039/100014842 14-003399 National Multiple Sclerosis Society https://doi.org/10.13039/100000890 FP-1607-25369 edited-state corrected-proof Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the National Institutes of Health (NIH) (National Institute of Neurological Disorders and Stroke R01NS062885 to D.P.), the National Multiple Sclerosis Society (Sylvia Lawry Physician Fellowship Award to I.C.G.), and the Race to Erase MS Foundation (14-003399 to C.J.A.). Publisher Copyright: {\textcopyright} The Author(s), 2019.",
year = "2021",
month = jan,
doi = "10.1177/1352458519887346",
language = "English (US)",
volume = "27",
pages = "130--133",
journal = "Multiple Sclerosis Journal",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
number = "1",
}