TY - JOUR
T1 - Cerebellar leptomeningeal enhancement
T2 - An imaging finding of rapidly progressive Purkinje cell cytoplasmic autoantibody type 1 paraneoplastic cerebellar syndrome
AU - Thakolwiboon, Smathorn
AU - Linnoila, Jenny
AU - Pittock, Sean J.
AU - Dubey, Divyanshu
AU - Zekeridou, Anastasia
N1 - Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/2/15
Y1 - 2024/2/15
N2 - Purkinje cell cytoplasmic autoantibody type 1 (PCA1), also known as anti-Yo, is a ‘high-risk’ paraneoplastic antibody, associated with rapidly progressive cerebellar syndrome. In patients with this syndrome, various MRI abnormalities have been documented, including atrophy in the cerebellum and brainstem, T2 hyperintensity in the brainstem and spinal cord, and cranial nerve enhancement. This report introduces an imaging finding, cerebellar leptomeningeal enhancement, which was observed in all three cases at early stages. Despite neurological deterioration, all patients underwent immunotherapy, and subsequent follow-up MRI revealed resolution of the leptomeningeal enhancement, suggesting that this feature is distinct from meningeal carcinomatosis.
AB - Purkinje cell cytoplasmic autoantibody type 1 (PCA1), also known as anti-Yo, is a ‘high-risk’ paraneoplastic antibody, associated with rapidly progressive cerebellar syndrome. In patients with this syndrome, various MRI abnormalities have been documented, including atrophy in the cerebellum and brainstem, T2 hyperintensity in the brainstem and spinal cord, and cranial nerve enhancement. This report introduces an imaging finding, cerebellar leptomeningeal enhancement, which was observed in all three cases at early stages. Despite neurological deterioration, all patients underwent immunotherapy, and subsequent follow-up MRI revealed resolution of the leptomeningeal enhancement, suggesting that this feature is distinct from meningeal carcinomatosis.
KW - Anti-Yo
KW - Leptomeningeal enhancement
KW - Paraneoplastic
KW - Purkinje cell cytoplasmic autoantibody type 1
KW - Rapidly progressive cerebellar syndrome
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UR - http://www.scopus.com/inward/citedby.url?scp=85183199082&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2024.578293
DO - 10.1016/j.jneuroim.2024.578293
M3 - Article
C2 - 38266443
AN - SCOPUS:85183199082
SN - 0165-5728
VL - 387
JO - Journal of neuroimmunology
JF - Journal of neuroimmunology
M1 - 578293
ER -