Central nervous system lymphoma: Histologic types and CT appearance

C. R. Jack, B. P. O'Neill, P. M. Banks, D. F. Reese

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


The distribution of histologic types of lymphoma according to the proposed working formulation was determined for 55 patients with primary central nervous system (CNS) non-Hodgkin lymphoma. Fifty-five percent of these patients had diffuse large-cell histologic features. When the relationship between histologic type and computed tomographic (CT) appearance was analyzed, the following trends were noted: A greater percentage of mixed cell tumors were multiple when compared with other types; noncleaved small-cell tumors were more commonly located in the central gray matter or corpus callosum than were other types; all immunoblastic tumors were enhanced homogeneously, unlike other types; and smaller tumors appeared to be associated with an increased histologic grade. Eleven patients had CT confirmation of a CNS recurrence; in eight patients, the recurrent tumor was in a different location than the original lesion. Eleven patients had associated intraocular lymphoma, and four were immunosuppressed.

Original languageEnglish (US)
Pages (from-to)211-215
Number of pages5
Issue number1
StatePublished - 1988

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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