TY - JOUR
T1 - Cellular senescence and the senescent secretory phenotype in age-related chronic diseases
AU - Zhu, Yi
AU - Armstrong, Jacqueline L.
AU - Tchkonia, Tamara
AU - Kirkland, James L.
PY - 2014/7
Y1 - 2014/7
N2 - Possible mechanisms in cellular senescence and the senescence-Associated secretory phenotype (SASP) that drive and promote chronic inflammation in multiple age-related chronic diseases are considered. RECENT FINDINGS: A series of studies about the SASP indicate that senescent cells may be involved in the development of chronic inflammatory diseases associated with aging. SUMMARY: Aging is a complex biological process accompanied by a state of chronic, low-grade, 'sterile' inflammation, which is a major contributor to the development of many age-related chronic disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes, cancers, and others. It appears that cellular senescence plays a role in causing inflammation through the SASP. A better understanding of the contribution of senescent cells to the pathologies of chronic inflammatory disorders could have potentially profound diagnostic and therapeutic implications.
AB - Possible mechanisms in cellular senescence and the senescence-Associated secretory phenotype (SASP) that drive and promote chronic inflammation in multiple age-related chronic diseases are considered. RECENT FINDINGS: A series of studies about the SASP indicate that senescent cells may be involved in the development of chronic inflammatory diseases associated with aging. SUMMARY: Aging is a complex biological process accompanied by a state of chronic, low-grade, 'sterile' inflammation, which is a major contributor to the development of many age-related chronic disorders including atherosclerosis, osteoarthritis, Alzheimer's disease, type 2 diabetes, cancers, and others. It appears that cellular senescence plays a role in causing inflammation through the SASP. A better understanding of the contribution of senescent cells to the pathologies of chronic inflammatory disorders could have potentially profound diagnostic and therapeutic implications.
KW - Inflammation
KW - Senescence
KW - Senescence-Associated secretory phenotype
UR - http://www.scopus.com/inward/record.url?scp=84902297367&partnerID=8YFLogxK
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U2 - 10.1097/MCO.0000000000000065
DO - 10.1097/MCO.0000000000000065
M3 - Review article
C2 - 24848532
AN - SCOPUS:84902297367
SN - 1363-1950
VL - 17
SP - 324
EP - 328
JO - Current opinion in clinical nutrition and metabolic care
JF - Current opinion in clinical nutrition and metabolic care
IS - 4
ER -