Cellular distribution of platelet-derived growth factor, transforming growth factor-β, basic fibroblast growth factor, and their receptors in normal bone marrow

Soo Young Yoon; Ayalew Tefferi; Chin Yang Li

doi:10.1159/000046507

Cellular distribution of platelet-derived growth factor, transforming growth factor-β, basic fibroblast growth factor, and their receptors in normal bone marrow

Soo Young Yoon, Ayalew Tefferi, Chin Yang Li

Hematology

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

We performed an immunohistochemical study on 5 normal marrow samples and 3 fibrotic marrow samples to investigate the cellular distribution of various isoforms of platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), basic fibroblast growth factor (bFGF), and their corresponding receptors. Immature hematopoietic precursors strongly expressed PDGF-B, all the TGF-β isoforms, PDGFRβ, TGFβRI and II, and FGFR1, 3, and 4. Megakaryocytes stained primarily for PDGF-B, TGF-β2-3 and PDGFRβ. Histiocytes displayed intense TGF-β1, bFGF, and FGFR2 expression. Fibroblasts and endothelial cells carried receptors for all the aforementioned cytokines. The last 2 cell types also expressed the ligand cytokines to varied degrees.

Original language	English (US)
Pages (from-to)	151-157
Number of pages	7
Journal	Acta Haematologica
Volume	104
Issue number	4
DOIs	https://doi.org/10.1159/000046507
State	Published - Dec 1 2000

Keywords

Basic fibroblast growth factor
Bone marrow
Cytokine
Immunohistochemistry
Isotype
Myelofibrosis
Platelet-derived growth factor
Receptors
Transforming growth factor-β

ASJC Scopus subject areas

Hematology

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10.1159/000046507

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title = "Cellular distribution of platelet-derived growth factor, transforming growth factor-β, basic fibroblast growth factor, and their receptors in normal bone marrow",

abstract = "We performed an immunohistochemical study on 5 normal marrow samples and 3 fibrotic marrow samples to investigate the cellular distribution of various isoforms of platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), basic fibroblast growth factor (bFGF), and their corresponding receptors. Immature hematopoietic precursors strongly expressed PDGF-B, all the TGF-β isoforms, PDGFRβ, TGFβRI and II, and FGFR1, 3, and 4. Megakaryocytes stained primarily for PDGF-B, TGF-β2-3 and PDGFRβ. Histiocytes displayed intense TGF-β1, bFGF, and FGFR2 expression. Fibroblasts and endothelial cells carried receptors for all the aforementioned cytokines. The last 2 cell types also expressed the ligand cytokines to varied degrees.",

keywords = "Basic fibroblast growth factor, Bone marrow, Cytokine, Immunohistochemistry, Isotype, Myelofibrosis, Platelet-derived growth factor, Receptors, Transforming growth factor-β",

author = "Yoon, {Soo Young} and Ayalew Tefferi and Li, {Chin Yang}",

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T1 - Cellular distribution of platelet-derived growth factor, transforming growth factor-β, basic fibroblast growth factor, and their receptors in normal bone marrow

AU - Yoon, Soo Young

AU - Tefferi, Ayalew

AU - Li, Chin Yang

PY - 2000/12/1

Y1 - 2000/12/1

N2 - We performed an immunohistochemical study on 5 normal marrow samples and 3 fibrotic marrow samples to investigate the cellular distribution of various isoforms of platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), basic fibroblast growth factor (bFGF), and their corresponding receptors. Immature hematopoietic precursors strongly expressed PDGF-B, all the TGF-β isoforms, PDGFRβ, TGFβRI and II, and FGFR1, 3, and 4. Megakaryocytes stained primarily for PDGF-B, TGF-β2-3 and PDGFRβ. Histiocytes displayed intense TGF-β1, bFGF, and FGFR2 expression. Fibroblasts and endothelial cells carried receptors for all the aforementioned cytokines. The last 2 cell types also expressed the ligand cytokines to varied degrees.

AB - We performed an immunohistochemical study on 5 normal marrow samples and 3 fibrotic marrow samples to investigate the cellular distribution of various isoforms of platelet-derived growth factor (PDGF), transforming growth factor-β (TGF-β), basic fibroblast growth factor (bFGF), and their corresponding receptors. Immature hematopoietic precursors strongly expressed PDGF-B, all the TGF-β isoforms, PDGFRβ, TGFβRI and II, and FGFR1, 3, and 4. Megakaryocytes stained primarily for PDGF-B, TGF-β2-3 and PDGFRβ. Histiocytes displayed intense TGF-β1, bFGF, and FGFR2 expression. Fibroblasts and endothelial cells carried receptors for all the aforementioned cytokines. The last 2 cell types also expressed the ligand cytokines to varied degrees.

KW - Basic fibroblast growth factor

KW - Bone marrow

KW - Cytokine

KW - Immunohistochemistry

KW - Isotype

KW - Myelofibrosis

KW - Platelet-derived growth factor

KW - Receptors

KW - Transforming growth factor-β

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JF - Acta Haematologica

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Cellular distribution of platelet-derived growth factor, transforming growth factor-β, basic fibroblast growth factor, and their receptors in normal bone marrow

Abstract

Keywords

ASJC Scopus subject areas

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