Cell-mediated therapies to facilitate operational tolerance in liver transplantation

Samia D. Ellias; Ellen L. Larson; Timucin Taner; Scott L. Nyberg

doi:10.3390/ijms22084016

Cell-mediated therapies to facilitate operational tolerance in liver transplantation

Samia D. Ellias, Ellen L. Larson, Timucin Taner, Scott L. Nyberg

Transplant Surgery

Research output: Contribution to journal › Article › peer-review

Abstract

Cell therapies using immune cells or non-parenchymal cells of the liver have emerged as potential treatments to facilitate immunosuppression withdrawal and to induce operational tolerance in liver transplant (LT) recipients. Recent pre-clinical and clinical trials of cellular therapies including regulatory T cells, regulatory dendritic cells, and mesenchymal cells have shown promising results. Here we briefly summarize current concepts of cellular therapy for induction of operational tolerance in LT recipients.

Original language	English (US)
Article number	4016
Journal	International journal of molecular sciences
Volume	22
Issue number	8
DOIs	https://doi.org/10.3390/ijms22084016
State	Published - Apr 2 2021

Keywords

Dendritic cells
Liver transplantation
Mesenchymal cells
Operational tolerance
Regulatory T cells
Transplant immunology

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms22084016

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title = "Cell-mediated therapies to facilitate operational tolerance in liver transplantation",

abstract = "Cell therapies using immune cells or non-parenchymal cells of the liver have emerged as potential treatments to facilitate immunosuppression withdrawal and to induce operational tolerance in liver transplant (LT) recipients. Recent pre-clinical and clinical trials of cellular therapies including regulatory T cells, regulatory dendritic cells, and mesenchymal cells have shown promising results. Here we briefly summarize current concepts of cellular therapy for induction of operational tolerance in LT recipients.",

keywords = "Dendritic cells, Liver transplantation, Mesenchymal cells, Operational tolerance, Regulatory T cells, Transplant immunology",

author = "Ellias, {Samia D.} and Larson, {Ellen L.} and Timucin Taner and Nyberg, {Scott L.}",

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AU - Larson, Ellen L.

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AU - Nyberg, Scott L.

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AB - Cell therapies using immune cells or non-parenchymal cells of the liver have emerged as potential treatments to facilitate immunosuppression withdrawal and to induce operational tolerance in liver transplant (LT) recipients. Recent pre-clinical and clinical trials of cellular therapies including regulatory T cells, regulatory dendritic cells, and mesenchymal cells have shown promising results. Here we briefly summarize current concepts of cellular therapy for induction of operational tolerance in LT recipients.

KW - Dendritic cells

KW - Liver transplantation

KW - Mesenchymal cells

KW - Operational tolerance

KW - Regulatory T cells

KW - Transplant immunology

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Cell-mediated therapies to facilitate operational tolerance in liver transplantation

Abstract

Keywords

ASJC Scopus subject areas

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