Cdc37 regulation of the kinome: when to hold 'em and when to fold 'em.

Larry M. Karnitz, Sara J. Felts

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations


Although massive genome sequencing efforts have identified the protein kinases encoded by several eukaryotic genomes and proteomic analyses have begun to determine the kinases expressed in a cell, there is still much to learn about the additional cellular events that shape eukaryotic kinomes. Large-scale analyses in Saccharomyces cerevisiae have indicated that a relatively small subset of kinases requires chaperoning by heat shock protein 90 (Hsp90). However, new evidence suggests that most kinases do require chaperoning and, furthermore, that Cdc37, a chaperone that has Hsp90-dependent and -independent functions, serves as the chaperone for a large portion of the yeast kinome.

Original languageEnglish (US)
Pages (from-to)pe22
JournalScience's STKE : signal transduction knowledge environment
Issue number385
StatePublished - May 26 2007

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Cdc37 regulation of the kinome: when to hold 'em and when to fold 'em.'. Together they form a unique fingerprint.

Cite this