TY - JOUR
T1 - CD8+ T Cells Keep Their (K+)urrency for Function
AU - Banuelos, Alma
AU - da Silva, Henrique Borges
N1 - Publisher Copyright:
©2023 American Association for Cancer Research.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - CD8+ T-cell responses are influenced by ion abundance, which can widely vary within the tumor microenvironment. In this issue, Collier and colleagues investigated how intracellular versus extracellular potassium ion (K+) regulates intratumoral CD8+ T cells. They show that, while excessive extracellular K+ induces exhaustion, intracellular K+ is needed for protection from dysfunction. This work shows additional evidence that the regulation of CD8+ T-cell responses depends on a fine balance between intracellular and extracellular metabolite levels. See related article by Collier et al., p. 36 (2) .
AB - CD8+ T-cell responses are influenced by ion abundance, which can widely vary within the tumor microenvironment. In this issue, Collier and colleagues investigated how intracellular versus extracellular potassium ion (K+) regulates intratumoral CD8+ T cells. They show that, while excessive extracellular K+ induces exhaustion, intracellular K+ is needed for protection from dysfunction. This work shows additional evidence that the regulation of CD8+ T-cell responses depends on a fine balance between intracellular and extracellular metabolite levels. See related article by Collier et al., p. 36 (2) .
UR - http://www.scopus.com/inward/record.url?scp=85181778215&partnerID=8YFLogxK
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U2 - 10.1158/2326-6066.CIR-23-0961
DO - 10.1158/2326-6066.CIR-23-0961
M3 - Comment/debate
C2 - 38063855
AN - SCOPUS:85181778215
SN - 2326-6066
VL - 12
SP - 6
JO - Cancer Immunology Research
JF - Cancer Immunology Research
IS - 1
ER -