CD5+ persistent polyclonal B-cell lymphocytosis in a male

Craig B. Reeder, Christopher R. Conley

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Persistent polyclonal B-cell lymphocytosis with binucleate lymphocytes is a rare lymphoproliferative syndrome of uncertain cause that is strongly associated with HLA-DR7 positivity, cigarette smoking, and female sex. As yet, there is no explanation for the strong sex predilection. We report the third case of persistent polyclonal B-cell lymphocytosis in a male. Other notable findings in this case are lack of HLA-DR7 and strong positive CD5 markers in the polyclonal B-cell population. To our knowledge, CD5 expression has not been mentioned or reported in association with this syndrome.

Original languageEnglish (US)
Pages (from-to)593-596
Number of pages4
JournalLeukemia and Lymphoma
Issue number5-6
StatePublished - 1999


  • B cells
  • Case history
  • Lymphocytes
  • Lymphoproliferative syndrome

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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