Julius Axelrod, Richard Weinshilboum

Research output: Contribution to journalReview articlepeer-review

120 Scopus citations


THE catecholamines — dopamine, adrenaline (epinephrine) and noradrenaline (norepinephrine) — are found at specific locations in tissues. Noradrenaline is present mainly in the sympathetic nerves of the peripheral and central nervous systems and acts locally on effector cells of vascular smooth muscle, adipose tissue, liver, heart and brain as a neurotransmitter. Adrenaline is primarily located in the adrenal medulla and acts mainly as a hormone on distant target organs after its release from the adrenal gland into the bloodstream. Dopamine has two functions: it serves as a precursor of noradrenaline, and it presumably functions as a neurotransmitter in the areas.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalNew England Journal of Medicine
Issue number5
StatePublished - Aug 3 1972

ASJC Scopus subject areas

  • General Medicine


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