TY - JOUR
T1 - Cataplexy emotional trigger questionnaire (CETQ) - A brief patient screen to identify cataplexy in patients with narcolepsy
AU - Moore, Wendy R.
AU - Silber, Micheal H.
AU - Decker, Paul A.
AU - Heim-Penokie, Patricia C.
AU - Sikkink, Vicki K.
AU - Slocumb, Nancy
AU - Richardson, Jarrett W.
AU - Krahn, Lois E.
PY - 2007/2/15
Y1 - 2007/2/15
N2 - Study Objectives: This pilot study explored the sensitivity and specificity of a brief survey to determine the presence of cataplexy. We hypothesized that the brief questionnaire could provide a quick, sensitive, and specific screening tool to identify those patients with cataplexy, which would result in more timely referrals for further diagnostic testing. Design: The pilot study utilized a brief questionnaire that was developed by including 5 questions that were found to be strong positive predictors of cataplexy from a previous 51-item cataplexy questionnaire. Setting: Participants with a laboratory-confirmed diagnosis completed the questionnaire via mail correspondence or at the time of scheduled appointments in the Mayo Clinic Sleep Disorder Center, Rochester, Minn. Participants: Seventy-eight patients with narcolepsy and cataplexy and 78 patients with obstructive sleep apnea completed the questionnaire. Interventions: NA. Measurements and Results: The sensitivity, specificity, area under the curve, positive predictive value, and negative predictive value/ were computed for each question individually, along with appropriate 95% confidence intervals. Conclusions: The first item of the cataplexy emotional trigger questionnaire (CETQ) discriminates patients with cataplexy from controls with excellent sensitivity and specificity. The addition of the other 4 questions, in the context of question 1, did not improve specificity, area under the curve, positive predictive value, or negative predictive value but did provide useful confirmatory data. Thus, a single question provides a brief practical tool that could improve the recognition of cataplexy in the clinical setting. Depending on the circumstance, users may be interested in utilizing 1 or all 5 questions.
AB - Study Objectives: This pilot study explored the sensitivity and specificity of a brief survey to determine the presence of cataplexy. We hypothesized that the brief questionnaire could provide a quick, sensitive, and specific screening tool to identify those patients with cataplexy, which would result in more timely referrals for further diagnostic testing. Design: The pilot study utilized a brief questionnaire that was developed by including 5 questions that were found to be strong positive predictors of cataplexy from a previous 51-item cataplexy questionnaire. Setting: Participants with a laboratory-confirmed diagnosis completed the questionnaire via mail correspondence or at the time of scheduled appointments in the Mayo Clinic Sleep Disorder Center, Rochester, Minn. Participants: Seventy-eight patients with narcolepsy and cataplexy and 78 patients with obstructive sleep apnea completed the questionnaire. Interventions: NA. Measurements and Results: The sensitivity, specificity, area under the curve, positive predictive value, and negative predictive value/ were computed for each question individually, along with appropriate 95% confidence intervals. Conclusions: The first item of the cataplexy emotional trigger questionnaire (CETQ) discriminates patients with cataplexy from controls with excellent sensitivity and specificity. The addition of the other 4 questions, in the context of question 1, did not improve specificity, area under the curve, positive predictive value, or negative predictive value but did provide useful confirmatory data. Thus, a single question provides a brief practical tool that could improve the recognition of cataplexy in the clinical setting. Depending on the circumstance, users may be interested in utilizing 1 or all 5 questions.
KW - Cataplexy
KW - Diagnosis
KW - Narcolepsy
KW - Screen
UR - http://www.scopus.com/inward/record.url?scp=34248570965&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248570965&partnerID=8YFLogxK
U2 - 10.5664/jcsm.26743
DO - 10.5664/jcsm.26743
M3 - Article
C2 - 17557451
AN - SCOPUS:34248570965
SN - 1550-9389
VL - 3
SP - 37
EP - 40
JO - Journal of Clinical Sleep Medicine
JF - Journal of Clinical Sleep Medicine
IS - 1
ER -