TY - JOUR
T1 - Case of mononeuritis multiplex onset with rituximab therapy for Waldenström's macroglobulinemia
AU - Mauermann, Michelle L.
AU - Ryan, Matthew L.
AU - Moon, Joon Shik
AU - Klein, Christopher J.
PY - 2007/9/15
Y1 - 2007/9/15
N2 - Waldenström's macroglobulinemia (WM) is a lymphoplasmacytic disorder with associated monoclonal gammopathy. A wide variety of neuropathies can be associated with WM, but most commonly it is a mild length-dependent sensory neuropathy of unclear etiology. Rituximab is a monoclonal antibody which suppresses mature B-cell populations. It has increasingly been used in wide applications including WM, especially in those cases with severe neuropathy. The highlighted case provides an example of rituximab treatment complication in a WM patient with mild sensory neuropathy that evolved to multiple mononeuropathies with features of systemic vasculitis and unusual conversion of type I to type II cryoglobulinemia.
AB - Waldenström's macroglobulinemia (WM) is a lymphoplasmacytic disorder with associated monoclonal gammopathy. A wide variety of neuropathies can be associated with WM, but most commonly it is a mild length-dependent sensory neuropathy of unclear etiology. Rituximab is a monoclonal antibody which suppresses mature B-cell populations. It has increasingly been used in wide applications including WM, especially in those cases with severe neuropathy. The highlighted case provides an example of rituximab treatment complication in a WM patient with mild sensory neuropathy that evolved to multiple mononeuropathies with features of systemic vasculitis and unusual conversion of type I to type II cryoglobulinemia.
KW - Cryoglobulinemia
KW - Mononeuritis multiplex
KW - Neuropathy
KW - Rituximab
KW - Vasculitis
KW - Waldenström's macroglobulinemia
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UR - http://www.scopus.com/inward/citedby.url?scp=34547657335&partnerID=8YFLogxK
U2 - 10.1016/j.jns.2007.04.009
DO - 10.1016/j.jns.2007.04.009
M3 - Article
C2 - 17537458
AN - SCOPUS:34547657335
SN - 0022-510X
VL - 260
SP - 240
EP - 243
JO - Journal of the neurological sciences
JF - Journal of the neurological sciences
IS - 1-2
ER -