Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease

Demetrius M. Maraganore; Matthew J. Farrer; John A. Hardy; Shannon K. McDonnell; Daniel J. Schaid; Walter A. Rocca

doi:10.1002/1531-8257(200007)15:4<714::AID-MDS1018>3.0.CO;2-3

Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease

Demetrius M. Maraganore, Matthew J. Farrer, John A. Hardy, Shannon K. McDonnell, Daniel J. Schaid, Walter A. Rocca

Quantitative Health Sciences

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

We investigated the association of Parkinson's disease (PD) with two genes encoding liver-detoxifying enzymes, debrisoquine 4-hydroxylase (CYP2D6) and N-acetyltransferase 2 (NAT2), and with one gene related to Alzheimer's disease, apolipoprotein E (APOE). In a sample of 139 unrelated PD cases and 113 control subjects, the NAT2 M3 allele was associated with PD (odds ratio = 7.9; 95% confidence interval = 1.7-36.3). Case-control analyses for CYP2D6, APOE, and NAT2 M1 or M2 did not show a significant association. However, the age at onset of PD was significantly earlier in cases with the APOE E2/E3 genotype than in cases with the E3/E3 genotype.

Original language	English (US)
Pages (from-to)	714-719
Number of pages	6
Journal	Movement Disorders
Volume	15
Issue number	4
DOIs	https://doi.org/10.1002/1531-8257(200007)15:4<714::AID-MDS1018>3.0.CO;2-3
State	Published - 2000

Keywords

APOE
CYP2D6
Case-control study
NAT2
Parkinson's disease
Susceptibility genes

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease",

abstract = "We investigated the association of Parkinson's disease (PD) with two genes encoding liver-detoxifying enzymes, debrisoquine 4-hydroxylase (CYP2D6) and N-acetyltransferase 2 (NAT2), and with one gene related to Alzheimer's disease, apolipoprotein E (APOE). In a sample of 139 unrelated PD cases and 113 control subjects, the NAT2 M3 allele was associated with PD (odds ratio = 7.9; 95% confidence interval = 1.7-36.3). Case-control analyses for CYP2D6, APOE, and NAT2 M1 or M2 did not show a significant association. However, the age at onset of PD was significantly earlier in cases with the APOE E2/E3 genotype than in cases with the E3/E3 genotype.",

keywords = "APOE, CYP2D6, Case-control study, NAT2, Parkinson's disease, Susceptibility genes",

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doi = "10.1002/1531-8257(200007)15:4<714::AID-MDS1018>3.0.CO;2-3",

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T1 - Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease

AU - Maraganore, Demetrius M.

AU - Farrer, Matthew J.

AU - Hardy, John A.

AU - McDonnell, Shannon K.

AU - Schaid, Daniel J.

AU - Rocca, Walter A.

PY - 2000

Y1 - 2000

N2 - We investigated the association of Parkinson's disease (PD) with two genes encoding liver-detoxifying enzymes, debrisoquine 4-hydroxylase (CYP2D6) and N-acetyltransferase 2 (NAT2), and with one gene related to Alzheimer's disease, apolipoprotein E (APOE). In a sample of 139 unrelated PD cases and 113 control subjects, the NAT2 M3 allele was associated with PD (odds ratio = 7.9; 95% confidence interval = 1.7-36.3). Case-control analyses for CYP2D6, APOE, and NAT2 M1 or M2 did not show a significant association. However, the age at onset of PD was significantly earlier in cases with the APOE E2/E3 genotype than in cases with the E3/E3 genotype.

AB - We investigated the association of Parkinson's disease (PD) with two genes encoding liver-detoxifying enzymes, debrisoquine 4-hydroxylase (CYP2D6) and N-acetyltransferase 2 (NAT2), and with one gene related to Alzheimer's disease, apolipoprotein E (APOE). In a sample of 139 unrelated PD cases and 113 control subjects, the NAT2 M3 allele was associated with PD (odds ratio = 7.9; 95% confidence interval = 1.7-36.3). Case-control analyses for CYP2D6, APOE, and NAT2 M1 or M2 did not show a significant association. However, the age at onset of PD was significantly earlier in cases with the APOE E2/E3 genotype than in cases with the E3/E3 genotype.

KW - APOE

KW - CYP2D6

KW - Case-control study

KW - NAT2

KW - Parkinson's disease

KW - Susceptibility genes

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AN - SCOPUS:0033941972

SN - 0885-3185

VL - 15

SP - 714

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JO - Movement Disorders

JF - Movement Disorders

IS - 4

ER -

Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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