Abstract
We investigated the association of Parkinson's disease (PD) with two genes encoding liver-detoxifying enzymes, debrisoquine 4-hydroxylase (CYP2D6) and N-acetyltransferase 2 (NAT2), and with one gene related to Alzheimer's disease, apolipoprotein E (APOE). In a sample of 139 unrelated PD cases and 113 control subjects, the NAT2 M3 allele was associated with PD (odds ratio = 7.9; 95% confidence interval = 1.7-36.3). Case-control analyses for CYP2D6, APOE, and NAT2 M1 or M2 did not show a significant association. However, the age at onset of PD was significantly earlier in cases with the APOE E2/E3 genotype than in cases with the E3/E3 genotype.
Original language | English (US) |
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Pages (from-to) | 714-719 |
Number of pages | 6 |
Journal | Movement Disorders |
Volume | 15 |
Issue number | 4 |
DOIs | |
State | Published - 2000 |
Keywords
- APOE
- CYP2D6
- Case-control study
- NAT2
- Parkinson's disease
- Susceptibility genes
ASJC Scopus subject areas
- Neurology
- Clinical Neurology