Abstract
l-Carnitine transport was studied in cultured muscle cells and skin fibroblasts of patients with primary systemic carnitine deficiency and control subjects. In both cell culture types, two systems for carnitine transport were identified. The kinetic parameters for carnitine transport were remarkably similar in cultured muscle cells and skin fibroblasts. Normal rates and kinetic properties of carnitine transport were observed for both cell lines from patients with systemic carnitine deficiency. These studies do not rule out a defect in carnitine transport in vivo.
Original language | English (US) |
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Pages (from-to) | 495-500 |
Number of pages | 6 |
Journal | In Vitro |
Volume | 18 |
Issue number | 5 |
DOIs | |
State | Published - May 1982 |
Keywords
- carnitine
- carnitine transport
- muscle cell culture
- primary systemic carnitine deficiency
- skin fibroblasts
ASJC Scopus subject areas
- Biotechnology
- Plant Science