Carisoprodol withdrawal after internet purchase

MacKram F. Eleid, Lois E. Krahn, Neera Agrwal, Brent P. Goodman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Introduction: Carisoprodol is a centrally acting muscle relaxant used in the treatment of various musculoskeletal disorders whose main metabolite, meprobamate, is a controlled substance in the United States due to its sedative properties and potential for abuse. Case description: We report a case of a 51-year-old man with cognitive impairment and tremor who developed worsening tremor, anxiety, myoclonus, ataxia, and psychosis on abrupt cessation of carisoprodol. At hospital discharge, his cognitive function significantly improved compared with when he was on carisoprodol. Conclusion: Carisoprodol withdrawal is an important and under-recognized syndrome that should be considered in patients presenting with neurologic symptoms who are taking the medication. Carisoprodol withdrawal can be successfully treated with the use of benzodiazepines, although further studies are needed to identify the most appropriate treatment protocol.

Original languageEnglish (US)
Pages (from-to)262-264
Number of pages3
Issue number4
StatePublished - Jul 2010


  • carisoprodol
  • myoclonus
  • psychosis
  • soma
  • withdrawal

ASJC Scopus subject areas

  • Clinical Neurology


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