Cardiovascular effects of microinjection of adenosine into the nucleus tractus solitarius

Robin A. Barraco; C. J. Janusz; P. M. Polasek; M. Parizon; P. A. Roberts

doi:10.1016/0361-9230(88)90016-0

Cardiovascular effects of microinjection of adenosine into the nucleus tractus solitarius

Robin A. Barraco, C. J. Janusz, P. M. Polasek, M. Parizon, P. A. Roberts

Medical GYN and Obstetrics

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

Rats were anesthetized with urethane and limited occipital craniotomy was conducted to expose the caudal medulla in the region of the obex. Microinjections of adenosine were made into the nucleus tractus solitarius and heart rate and blood pressure responses recorded. Adenosine produced dose-related decreases in blood pressure and heart rate. The data indicate that adenosine may play a neuromodulatory role in central cardiovascular control areas.

Original language	English (US)
Pages (from-to)	129-132
Number of pages	4
Journal	Brain Research Bulletin
Volume	20
Issue number	1
DOIs	https://doi.org/10.1016/0361-9230(88)90016-0
State	Published - Jan 1988

Keywords

Adenosine
Blood pressure
Heart rate
Nucleus tractus solitarius

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0361-9230(88)90016-0

Cite this

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title = "Cardiovascular effects of microinjection of adenosine into the nucleus tractus solitarius",

abstract = "Rats were anesthetized with urethane and limited occipital craniotomy was conducted to expose the caudal medulla in the region of the obex. Microinjections of adenosine were made into the nucleus tractus solitarius and heart rate and blood pressure responses recorded. Adenosine produced dose-related decreases in blood pressure and heart rate. The data indicate that adenosine may play a neuromodulatory role in central cardiovascular control areas.",

keywords = "Adenosine, Blood pressure, Heart rate, Nucleus tractus solitarius",

author = "Barraco, {Robin A.} and Janusz, {C. J.} and Polasek, {P. M.} and M. Parizon and Roberts, {P. A.}",

note = "Funding Information: This researchw as supportedb y grantsf rom NSF (RI 186-04084), NIH (RR-08167-09a)n d the American Heart Association of Michigan. The authorsa cknowledget he technicalh elp of E. P. Schoener and W. R. Campbell.",

year = "1988",

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doi = "10.1016/0361-9230(88)90016-0",

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T1 - Cardiovascular effects of microinjection of adenosine into the nucleus tractus solitarius

AU - Barraco, Robin A.

AU - Janusz, C. J.

AU - Polasek, P. M.

AU - Parizon, M.

AU - Roberts, P. A.

N1 - Funding Information: This researchw as supportedb y grantsf rom NSF (RI 186-04084), NIH (RR-08167-09a)n d the American Heart Association of Michigan. The authorsa cknowledget he technicalh elp of E. P. Schoener and W. R. Campbell.

PY - 1988/1

Y1 - 1988/1

N2 - Rats were anesthetized with urethane and limited occipital craniotomy was conducted to expose the caudal medulla in the region of the obex. Microinjections of adenosine were made into the nucleus tractus solitarius and heart rate and blood pressure responses recorded. Adenosine produced dose-related decreases in blood pressure and heart rate. The data indicate that adenosine may play a neuromodulatory role in central cardiovascular control areas.

AB - Rats were anesthetized with urethane and limited occipital craniotomy was conducted to expose the caudal medulla in the region of the obex. Microinjections of adenosine were made into the nucleus tractus solitarius and heart rate and blood pressure responses recorded. Adenosine produced dose-related decreases in blood pressure and heart rate. The data indicate that adenosine may play a neuromodulatory role in central cardiovascular control areas.

KW - Adenosine

KW - Blood pressure

KW - Heart rate

KW - Nucleus tractus solitarius

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Cardiovascular effects of microinjection of adenosine into the nucleus tractus solitarius

Abstract

Keywords

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