Cardiovascular Disease Burden and Risk Factors Before and After Kidney Transplant

Mira T. Keddis, Gauri Bhutani, Ziad M. El-Zoghby

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Cardiovascular (CV) disease is the most common cause of mortality among kidney transplant candidates on the waiting-list and after kidney transplantation. The mechanisms of cardiovascular disease burden after transplant are multifactorial and the risk is largely determined by pre-transplant factors including CV disease and dialysis duration. Current pre-transplant cardiac evaluation protocols have proven to be inconsistent in predicting adverse cardiovascular outcome post-transplant. However, multiple biomarkers have been recognized as predictors of all-cause mortality and cardiovascular events including graft function, hemoglobin, homocysteine, C - reactive protein among others. Of these, elevation in the biomarker cardiac troponin T appears to be a significant predictor of cardiovascular events and mortality among wait-listed kidney transplant candidates and after transplantation. The relationship between CV risk reduction, normalization of cardiac troponin T levels and restoration of renal function after kidney transplant is complex but opens opportunities for the use of cardiac troponin T and other cardiovascular biomarkers as important endpoints of clinical interventions in kidney transplant recipients.

Original languageEnglish (US)
Pages (from-to)185-194
Number of pages10
JournalCardiovascular and Hematological Disorders - Drug Targets
Issue number3
StatePublished - Jan 1 2014


  • Cardiovascular disease
  • Kidney transplant
  • Risk factors

ASJC Scopus subject areas

  • Molecular Medicine
  • Hematology
  • Pharmacology
  • Cardiology and Cardiovascular Medicine


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