Cardiovagal autonomic function in HIV-infected patients with unsuppressed HIV viremia

Dominic C. Chow, Robert Wood, Julia Choi, Andrew Grandinetti, Mariana Gerschenson, Narin Sriratanaviriyakul, Beau Nakamoto, Cecilia Shikuma, Phillip Low

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Purpose: HIV infection has been implicated in dysregulationofthe autonomic nervous system. Method: Cross-sectional study exam ining the relationship between the presence of persistent detectable HIV viral load with autonomic function, measured by heart rate variability (HRV). Non-virologic suppression (NVS) was defined as having a detectable viral load for at least 3 months prior to autonomic function testing. HRV was measured during the following 4 maneuvers: resting and paced respirations and sustained handgrip and tilt. Inferences on parasympathetic and sympathetic modulations were determined by analyzing time and frequency domains of HRV. Results: 57 participants were enrolled in 3 groups: 22 were HIV-infected participants with HIVvirologic suppression (VS; undetectable HIV viral load), 9 were HIV-infected participants who had NVS, and 26 were HIV seronegative controls. There were lower time domain parameters in the HIV-infected group as a whole compared to controls. There were no significant differences in time domain parameters among HIV-infected participants. There were no differences in frequency domain parameters during any of the maneuvers between controls and all HIV-infected participants, nor between the NVS and VS groups. Conclusion: There were differences in autonomic function between HIV-infected individuals and HIV seronegative controls, but not between the NVS and VS groups.

Original languageEnglish (US)
Pages (from-to)141-150
Number of pages10
JournalHIV Clinical Trials
Issue number3
StatePublished - Jan 1 2011


  • HIV
  • acquired immune deficiency syndrome
  • autonomic dysfunction
  • heart rate variability
  • viremia

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)


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